Structure–Kinetic Relationship Studies for the Development of Long Residence Time LpxC Inhibitors-Reference-Cited by-同舟云学术

Structure–Kinetic Relationship Studies for the Development of Long Residence Time LpxC Inhibitors

Published:2022-08-29 Issue:17 Volume:65 Page:11854-11875
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Basak Sneha,Li Yong,Tao Suyuan^ORCID,Daryaee Fereidoon,Merino Jonathan,Gu Chendi,Delker Silvia L.¹,Phan Jenny N.²,Edwards Thomas E.³^ORCID,Walker Stephen G.,Tonge Peter J.^ORCID

Affiliation:

1. UCB, 87 Cambridge Park Drive, Cambridge, Massachusetts 01240, United States

2. McGill University, Montreal, Quebec H3A 0G4, Canada

3. UCB, 7869 NE Day Road, West Bainbridge Island, Washington 98110, United States

Funder

National Heart, Lung, and Blood Institute

National Institute of Allergy and Infectious Diseases

Center for Biotechnology, Stony Brook University

Brookhaven National Laboratory

National Institute of General Medical Sciences

Cold Spring Harbor Laboratory

Feinstein Institute for Medical Research

New York State Department of Economic Development

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00974

Reference63 articles.

1. Biochemical mechanisms of drug action: what does it take for success?

2. Drug–target residence time and its implications for lead optimization

3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action

4. The drug–target residence time model: a 10-year retrospective

5. Drug–target residence time: critical information for lead optimization

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