Unveiling the Selectivity Mechanism of Type-I LRRK2 Inhibitors by Computational Methods: Insights from Binding Thermodynamics and Kinetics Simulation
Author:
Affiliation:
1. College of Chemistry and Chemical Engineering, Lanzhou University, 730000 Lanzhou, Gansu, China
2. Ping An Healthcare Technology, 100000 Beijing, China
3. Faculty of Applied Science, Macao Polytechnic University, 999078 Macao SAR, China
Funder
Fundo para o Desenvolvimento das Ciências e da Tecnologia
National Natural Science Foundation of China
Publisher
American Chemical Society (ACS)
Subject
Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.3c00338
Reference55 articles.
1. Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology
2. Parkinson disease-associated cognitive impairment
3. From The Cover: Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
4. The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
5. LRRK2 kinase in Parkinson's disease
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