Dehydration of primary amides to nitriles in water. Late-stage functionalization and 1-pot multistep chemoenzymatic processes under micellar catalysis conditions-Reference-Cited by-同舟云学术

Dehydration of primary amides to nitriles in water. Late-stage functionalization and 1-pot multistep chemoenzymatic processes under micellar catalysis conditions

Published:2022 Issue:7 Volume:24 Page:2853-2858
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Wood Alex B.¹^ORCID,Kincaid Joseph R. A.¹^ORCID,Lipshutz Bruce H.¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA

Abstract

Palladium-catalyzed dehydration of primary amides to the corresponding nitriles can be performed in aqueous micelles, without need of significant volumes of organic co-solvent.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/GC/D1GC04671C

Reference47 articles.

1. Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

2. Nitrile-containing pharmaceuticals: target, mechanism of action, and their SAR studies

3. Application of Nitrile in Drug Design

4. Preparation of Nitriles from Halides and Sodium Cyanide. An Advantageous Nucleophilic Displacement in Dimethyl Sulfoxide1a

5. Significantly Enhanced Reactivities of the Nucleophilic Substitution Reactions in Ionic Liquid

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