Aqueous Extract of Dillenia indica Fruit (AEDI): A Sustainable Biocatalyst for the Synthesis of Pharmacologically Important Bis(indolyl)methanes

Abstract

AbstractA highly effective green technique for the synthesis of bis(indolyl) methanes mediated by ‘Aqueous Extract of Dillenia indica’ (AEDI) is developed. The reaction involves a simple procedure at a moderate temperature of below 60 °C in air within a short reaction time of 30–60 minutes under conditions free from external promoters, acids, ligands/organic media using our natural water–extracted catalyst, affording moderate to high yield. This protocol offers a mild, effective, and highly economical alternative to the existing protocols and promotes a more environmentally friendly alternative for the protic and Lewis acids catalysts that are already in use.