Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore-Reference-Cited by-同舟云学术

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Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

Published:2010-08-30 Issue:22 Volume:53 Page:7902-7917
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Fleming Fraser F.¹,Yao Lihua¹,Ravikumar P. C.¹,Funk Lee²,Shook Brian C.³

Affiliation:

1. Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, Pennsylvania 15282-1530

2. Mylan Pharmaceuticals Inc., 781 Chestnut Ridge Road, Morgantown, West Virginia 26505

3. Johnson & Johnson Pharmaceutical Research and Development, L.L.C., Welsh and McKean Roads, P.O. Box 776, Spring House, Pennsylvania 19477

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100762r

Reference256 articles.

1. The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents

2. In Vitro Metabolism of Aromatic Nitriles

3. A simple in vitro assay for assessing the reactivity of nitrile containing compounds

4. A generally applicable method for assessing the electrophilicity and reactivity of diverse nitrile-containing compounds

5. Investigation of ketone warheads as alternatives to the nitrile for preparation of potent and selective cathepsin K inhibitors

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