Radiation responsive PROTAC nanoparticles for tumor-specific proteolysis enhanced radiotherapy-Reference-Cited by-同舟云学术

Radiation responsive PROTAC nanoparticles for tumor-specific proteolysis enhanced radiotherapy

Published:2024 Issue:13 Volume:12 Page:3240-3248
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Xu Mengxia¹,Yun Yuyang¹²,Li Changjun¹,Ruan Yiling¹,Muraoka Osamu³,Xie Weijia²^ORCID,Sun Xiaolian¹^ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines, Key Laboratory of Drug Quality Control and Pharmacovigilance, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China

2. State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China

3. Faculty of Pharmacy, Kinki University, Higashiosaka, Osaka 577-8502, Japan

Abstract

An X-ray responsive RCNprotac with enhanced tumor accumulation for BRD4 proteolysis and enhanced radiosensitization is reported.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

China Pharmaceutical University

Outstanding Youth Foundation of Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D3TB03046F