Proteolysis-targeting drug delivery system (ProDDS): integrating targeted protein degradation concepts into formulation design-Reference-Cited by-同舟云学术

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Proteolysis-targeting drug delivery system (ProDDS): integrating targeted protein degradation concepts into formulation design

Published:2024 Issue: Volume: Page:
ISSN:0306-0012
Container-title:Chemical Society Reviews
language:en
Short-container-title:Chem. Soc. Rev.

Author:

Chen Yu¹²³^ORCID,Liu Fengyuan¹^ORCID,Pal Samira¹,Hu Quanyin¹²³^ORCID

Affiliation:

1. Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA

2. Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA

3. Wisconsin Center for NanoBioSystems, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA

Abstract

This review proposes the concept of proteolysis-targeting drug delivery system (ProDDS), surveys the recent research in various ProDDSs, summarizes their design principles, and provides an outlook on future opportunities.

Funder

American Cancer Society

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CS/D4CS00411F

Reference206 articles.

1. LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation

2. Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications

3. Kinase drug discovery 20 years after imatinib: progress and future directions

4. Kinase-targeted cancer therapies: progress, challenges and future directions

5. Cancer nanomedicine toward clinical translation: Obstacles, opportunities, and future prospects

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