Proteolysis-targeting chimera (PROTAC) delivery system: advancing protein degraders towards clinical translation-Reference-Cited by-同舟云学术

Proteolysis-targeting chimera (PROTAC) delivery system: advancing protein degraders towards clinical translation

Published:2022 Issue:13 Volume:51 Page:5330-5350
ISSN:0306-0012
Container-title:Chemical Society Reviews
language:en
Short-container-title:Chem. Soc. Rev.

Author:

Chen Yu¹²³,Tandon Ira¹,Heelan William¹^ORCID,Wang Yixin¹²³,Tang Weiping¹,Hu Quanyin¹²³^ORCID

Affiliation:

1. Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA

2. Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA

3. Wisconsin Center for NanoBioSystems, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA

Abstract

This tutorial review discusses the convergence of drug delivery systems and PROTACs, surveys the burgeoning PROTAC delivery strategies, summarizes their design principles, clarifies their challenges, and outlooks future translational opportunities.

Funder

University of Wisconsin-Madison

National Institutes of Health

Wisconsin Alumni Research Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CS/D1CS00762A

Reference59 articles.

1. Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

2. Advancing targeted protein degradation for cancer therapy

3. The PROTAC gold rush

4. Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

5. The role of reversible and irreversible covalent chemistry in targeted protein degradation

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