A photoactivatable upconverting nanodevice boosts the lysosomal escape of PROTAC degraders for enhanced combination therapy-Reference-Cited by-同舟云学术

A photoactivatable upconverting nanodevice boosts the lysosomal escape of PROTAC degraders for enhanced combination therapy

Published:2024 Issue:14 Volume:12 Page:3686-3699
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Zhan Jiayin¹,Li Xiang¹,Mu Yueru¹,Yao Huiqin²,Zhu Jun-Jie¹^ORCID,Zhang Jingjing¹³^ORCID

Affiliation:

1. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

2. Department of Medical Chemistry, College of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China

3. Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China

Abstract

A near-infrared light-controlled PROTAC delivery nanodevice achieves enhanced protein degradation efficiency and synergistic therapeutic efficacy in combination with NIR light-triggered photodynamic therapy.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/BM/D4BM00548A

Reference48 articles.

1. A PROTAC Augmenter for Photo‐Driven Pyroptosis in Breast Cancer

2. Radiation responsive PROTAC nanoparticles for tumor-specific proteolysis enhanced radiotherapy

3. Targeted protein degradation directly engaging lysosomes or proteasomes

4. Cooperatively designed aptamer-PROTACs for spatioselective degradation of nucleocytoplasmic shuttling protein for enhanced combinational therapy

5. A cocktail therapeutic strategy based on clofarabine-containing aptamer-PROTAC for enhanced cancer therapy

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