Development and optimization of a competitive binding assay for the galactophilic low affinity lectin LecA from Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Development and optimization of a competitive binding assay for the galactophilic low affinity lectin LecA from Pseudomonas aeruginosa

Published:2016 Issue:33 Volume:14 Page:7933-7948
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Joachim Ines¹²³⁴⁵,Rikker Sebastian⁶⁷⁸⁴,Hauck Dirk¹²³⁴⁵,Ponader Daniela⁹¹⁰¹¹¹²⁴,Boden Sophia¹³¹⁴¹⁵⁴,Sommer Roman¹²³⁴⁵,Hartmann Laura¹³¹⁴¹⁵⁴,Titz Alexander¹²³⁴⁵

Affiliation:

1. Chemical Biology of Carbohydrates

2. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)

3. D-66123 Saarbrücken

4. Germany

5. Deutsches Zentrum für Infektionsforschung (DZIF)

6. Department of Chemistry and Graduate School Chemical Biology

7. University of Konstanz

8. D-78457 Konstanz

9. Max Planck Institute of Colloids and Interfaces

10. Department of Biomolecular Systems

11. Research Campus Golm

12. 14424 Potsdam

13. Heinrich-Heine-University Duesseldorf

14. Institute of Organic Chemistry and Macromolecular Chemistry

15. D-40225 Düsseldorf

Abstract

Inhibition of LecA with its carbohydrate ligands results in reduced biofilm mass, a potential Achilles heel for treatment.

Funder

Helmholtz Association

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01313A

Reference86 articles.

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