Switch-on luminescent sensing of unlabelled bacterial lectin by terbium(iii) glycoconjugate systems

Author:

Wojtczak Karolina1ORCID,Zahorska Eva234ORCID,Murphy Ian J.1,Koppel Finnja5,Cooke Gordon5ORCID,Titz Alexander234ORCID,Byrne Joseph P.16ORCID

Affiliation:

1. School of Biological and Chemical Sciences, University of Galway, University Road, Galway, Ireland

2. Chemical Biology of Carbohydrates, Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research, Saarbrücken D-66123, Germany

3. Department of Chemistry, Saarland University, Saarbrücken D-66123, Germany

4. Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, Braunschweig, Germany

5. School of Chemical & BioPharmaceutical Sciences, Technological University Dublin, Dublin, Ireland

6. School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland

Abstract

Unlabelled bacterial lectin LecA causes enhancement of terbium(iii)-centred emission from glycoconjugate, with sensing driven by the lectin's selective carbohydrate-binding.

Funder

Science Foundation Ireland

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Reference38 articles.

1. WHO , Prioritization of pathogens to guide discovery, research and development of new antibiotics for drug-resistant bacterial infections, including tuberculosis , World Health Organisation , Geneva , 2017

2. Structures of the lectins from Pseudomonas aeruginosa: insights into the molecular basis for host glycan recognition

3. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

4. Diagnosis of bacterial infection

5. An oxime-based glycocluster microarray

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