A step forward in the sigma enigma: a role for chirality in the sigma1 receptor–ligand interaction?-Reference-Cited by-同舟云学术

A step forward in the sigma enigma: a role for chirality in the sigma1 receptor–ligand interaction?

Published:2015 Issue:1 Volume:6 Page:138-146
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Rossi Daniela¹²³⁴⁵,Marra Annamaria¹²³⁴⁵,Rui Marta¹²³⁴⁵,Laurini Erik⁶⁷⁵,Fermeglia Maurizio⁶⁷⁵,Pricl Sabrina⁶⁷⁵⁸⁹,Schepmann Dirk¹⁰¹¹¹²¹³,Wuensch Bernhard¹⁰¹¹¹²¹³,Peviani Marco¹⁴¹⁵³⁴⁵,Curti Daniela¹⁴¹⁵³⁴⁵,Collina Simona¹²³⁴⁵

Affiliation:

1. Department of Drug Sciences

2. Medicinal Chemistry and Pharmaceutical Technology section

3. University of Pavia

4. 27100 Pavia

5. Italy

6. MOSE – DEA-University of Trieste

7. 34127 Trieste

8. National Interuniversity Consortium for Material Science and Technology (INSTM)

9. Research Unit MOSE-DEA University of Trieste

10. Institute of Pharmaceutical and Medicinal Chemistry

11. University of Muenster

12. 48149 Muenster

13. Germany

14. Department of Biology and Biotechnology “L. Spallanzani”

15. Laboratory of Cellular and Molecular Neuropharmacology

Abstract

To investigate the role of chirality in the ligand–σ₁ receptor interaction, a series of enantiomeric arylalkylaminoalcohols and arylpyrrolidinols was evaluated by means of both in silico and in vitro studies.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C4MD00349G

Reference47 articles.

1. Sigma receptors: recent advances and new clinical potentials

2. A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain

3. Regulation of σ receptors and responsiveness to guanine nucleotides following repeated exposure of rats to haloperidol: further evidence for multiple σ binding sites

4. A proposal for the classification of sigma binding sites

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