A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain

Author:

Hellewell Susan B.,Bowen Wayne D.

Publisher

Elsevier BV

Subject

Developmental Biology,Clinical Neurology,Molecular Biology,General Neuroscience

Reference45 articles.

1. Labeling of the haloperidol-sensitive sigma receptor in NCB-20 hybrid neuroblastoma cells with [3H]-(1,3)-di-ortho-tolyl-guanidine and identification of the binding subunit by photoaffinity labeling with [3H]-m-azido-di-ortho-tolyl-ganidine;Adams;Soc. Neurosci. Abstr.,1987

2. Characterization of sigma receptors on PC12 cells: pharmacological differences from rat and guinea pig brain indicate sigma receptor heterogeneity;Bowen;Soc. Neurosci. Abstr.,1988

3. Evidence for a multisite model of the rat brain sigma receptor;Bowen;Eur. J. Pharmacol.,1989

4. Sigma receptors negatively modulate agonist-stimulated phosphoinositide metabolism in rat brain;Bowen;Eur. J. Pharmacol.,1988

5. Bowen, W.D., Tolentino, P.J., Kirschner, B.N., Varghese, P., de Costa, B.R. and Rice, K.C., Sigma receptors and signal transduction: negative modulation of signalling through phosphoinositide-linked receptor systems. In E.B. DeSouza, E.D. London and D.H. Clouet (Eds.),Sigma, PCP, and NMDA Receptor Systems — National Institute on Drug Abuse Research Monograph Series, U.S. Government Printing Office, Washington, DC, in press.

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