(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties-Reference-Cited by-同舟云学术

(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties

Published:2017-12-20 Issue:1 Volume:61 Page:372-384
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Amata Emanuele¹^ORCID,Rescifina Antonio¹^ORCID,Prezzavento Orazio¹^ORCID,Arena Emanuela¹,Dichiara Maria¹,Pittalà Valeria¹,Montilla-García Ángeles²,Punzo Francesco¹^ORCID,Merino Pedro³^ORCID,Cobos Enrique J.²,Marrazzo Agostino¹^ORCID

Affiliation:

1. Dipartimento di Scienze del Farmaco, Università di Catania, Viale A. Doria 6, 95125 Catania, Italy

2. Institute of Neuroscience and Department of Pharmacology, Faculty of Medicine, University of Granada, Avenida de Madrid 11, E-18012 Granada, Spain

3. Laboratorio de Síntesis Asimétrica, Departamento de Síntesis y Estructura de Biomoléculas, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), Universidad de Zaragoza, CSIC, Campus San Francisco, E-50009 Zaragoza, Aragón, Spain

Funder

Universita di Catania

Junta de Andalucia

Spanish Ministry of Economy and Competitiveness

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01584

Reference88 articles.

1. Evaluation of N-substitution in 6,7-benzomorphan compounds