A parallel permeability assay of peptides across artificial membranes and cell monolayers using a fluorogenic reaction-Reference-Cited by-同舟云学术

A parallel permeability assay of peptides across artificial membranes and cell monolayers using a fluorogenic reaction

Published:2019 Issue:11 Volume:17 Page:2887-2891
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Morimoto Jumpei¹²³⁴⁵^ORCID,Amano Rei¹²³⁴⁵,Ono Takahiro¹²³⁴⁵,Sando Shinsuke¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry and Biotechnology

2. Graduate School of Engineering

3. The University of Tokyo

4. Tokyo 113-8656

5. Japan

Abstract

An alkyne tag and a fluorogenic reaction enabled the rapid parallel evaluation of membrane permeability of peptides across artificial membranes and cell monolayers.

Funder

Core Research for Evolutional Science and Technology

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB00133F

Reference23 articles.

1. Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules

2. Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance

3. Conformational Flexibility, Internal Hydrogen Bonding, and Passive Membrane Permeability: Successful in Silico Prediction of the Relative Permeabilities of Cyclic Peptides

4. Testing the Conformational Hypothesis of Passive Membrane Permeability Using Synthetic Cyclic Peptide Diastereomers

5. On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Development and Application of Methodologies for Measuring Passive Membrane Permeability of Peptides toward Understanding the Structure-permeability Relationship of Cyclic Peptides;Journal of Synthetic Organic Chemistry, Japan;2024-06-01

2. Liposomal Permeation Assay for Droplet-Scale Pharmacokinetic Screening;Journal of Medicinal Chemistry;2023-04-19

3. Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides;Nature Communications;2023-03-17

4. Impact of Cyclization and Methylation on Peptide Penetration through Droplet Interface Bilayers;Langmuir;2022-04-22

5. Chiral lipid bilayers are enantioselectively permeable;Nature Chemistry;2021-06-10