Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules-Reference-Cited by-同舟云学术

Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules

Published:2017-01-25 Issue:5 Volume:60 Page:1665-1672
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pye Cameron R.¹^ORCID,Hewitt William M.¹^ORCID,Schwochert Joshua¹,Haddad Terra D.¹,Townsend Chad E.¹,Etienne Lyns¹,Lao Yongtong¹,Limberakis Chris²,Furukawa Akihiro³,Mathiowetz Alan M.⁴,Price David A.⁴,Liras Spiros⁴,Lokey R. Scott¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, United States

2. World Wide Medicinal Chemistry, Groton Laboratories, Pfizer Inc., Groton, Connecticut 06340, United States

3. Modality Research Laboratories, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan

4. World Wide Medicinal Chemistry, Cambridge Laboratories, Pfizer Inc., Cambridge, Massachusetts 02139, United States

Funder

Pfizer

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01483

Reference44 articles.

1. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

2. Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates

3. Use of 3D Properties to Characterize Beyond Rule-of-5 Property Space for Passive Permeation

4. How proteins bind macrocycles

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