On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds-Reference-Cited by-同舟云学术

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

Published:2011-09-25 Issue:11 Volume:7 Page:810-817
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

White Tina R,Renzelman Chad M,Rand Arthur C,Rezai Taha,McEwen Cayla M,Gelev Vladimir M,Turner Rushia A,Linington Roger G,Leung Siegfried S F,Kalgutkar Amit S,Bauman Jonathan N,Zhang Yizhong,Liras Spiros,Price David A,Mathiowetz Alan M,Jacobson Matthew P,Lokey R Scott

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.664.pdf

Reference32 articles.

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3. Kim, Y.K. et al. Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space. J. Am. Chem. Soc. 126, 14740–14745 (2004).

4. Biron, E. et al. Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues. Angew. Chem. Int. Edn Engl. 47, 2595–2599 (2008).

5. Doedens, L. et al. Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies. J. Am. Chem. Soc. 132, 8115–8128 (2010).

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