Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance

Published:2012 Issue:10 Volume:3 Page:1282-1289
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Rand Arthur C.¹²³,Leung Siegfried S. F.⁴⁵⁶³,Eng Heather⁷⁸⁹³,Rotter Charles J.⁷⁸⁹³,Sharma Raman⁷⁸⁹³,Kalgutkar Amit S.⁷⁸⁹³,Zhang Yizhong⁷⁸⁹³,Varma Manthena V.⁷⁸⁹³,Farley Kathleen A.¹⁰⁸⁹³,Khunte Bhagyashree¹⁰⁸⁹³,Limberakis Chris¹⁰⁸⁹³,Price David A.¹⁰⁸¹¹³,Liras Spiros¹⁰⁸¹¹³,Mathiowetz Alan M.¹⁰⁸¹¹³,Jacobson Matthew P.⁴⁵⁶³,Lokey R. Scott¹²³

Affiliation:

1. Department of Chemistry

2. University of California Santa Cruz

3. USA

4. Department of Pharmaceutical Chemistry

5. University of California San Francisco

6. San Francisco

7. Pharmacokinetics and Drug Metabolism

8. Pfizer Inc

9. Groton

10. Worldwide Medicinal Chemistry

11. Cambridge

Abstract

The impact of side chain functionality on the pharmacokinetics of an orally bioavailable cyclic peptide scaffold is investigated.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2012/MD/C2MD20203D

Reference28 articles.

1. On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

2. Development of a new permeability assay using low‐efflux MDCKII cells

3. High Throughput ADME Screening: Practical Considerations, Impact on the Portfolio and Enabler of In Silico ADME Models

4. Absorption enhancement, mechanistic and toxicity studies of medium chain fatty acids, cyclodextrins and bile salts as peroral absorption enhancers

5. Testing the Conformational Hypothesis of Passive Membrane Permeability Using Synthetic Cyclic Peptide Diastereomers

Cited by 122 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Development and Application of Methodologies for Measuring Passive Membrane Permeability of Peptides toward Understanding the Structure-permeability Relationship of Cyclic Peptides;Journal of Synthetic Organic Chemistry, Japan;2024-06-01

2. Multi_CycGT: A Deep Learning-Based Multimodal Model for Predicting the Membrane Permeability of Cyclic Peptides;Journal of Medicinal Chemistry;2024-01-25

3. Cell penetration of oxadiazole-containing macrocycles;RSC Chemical Biology;2024

4. Multi-site esterification: a tunable, reversible strategy to tailor therapeutic peptides for delivery;Molecular Systems Design & Engineering;2024

5. Factors affecting peptide and protein absorption, metabolism, and excretion;Peptide and Protein Drug Delivery Using Polysaccharides;2024

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号京ICP备18003416号-3