Synthesis, ribosomal selectivity, and antibacterial activity of netilmicin 4′-derivatives-Reference-Cited by-同舟云学术

Synthesis, ribosomal selectivity, and antibacterial activity of netilmicin 4′-derivatives

Published:2019 Issue:6 Volume:10 Page:946-950
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Sonousi Amr¹²³⁴,Shcherbakov Dimitri⁵⁶⁷⁸,Vasella Andrea⁹¹⁰¹¹⁸,Böttger Erik C.⁵⁶⁷⁸,Crich David¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Wayne State University

3. Detroit

4. USA

5. Institut für Medizinische Mikrobiologie

6. Universität Zürich

7. 8006 Zürich

8. Switzerland

9. Laboratorium für Organische Chemie

10. ETH Zürich

11. 8093 Zürich

Abstract

We describe the synthesis and evaluation of 4′-subsituted netilmicin derivatives by selective functionalization at the 4′-position of the endocyclic enolether function.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

National Institute of Allergy and Infectious Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00153K

Reference20 articles.

1. 4′-O-substitutions determine selectivity of aminoglycoside antibiotics

2. Identification and Evaluation of Improved 4′- O -(Alkyl) 4,5-Disubstituted 2-Deoxystreptamines as Next-Generation Aminoglycoside Antibiotics

3. Synthesis and Antiribosomal Activities of 4′-O-, 6′-O-, 4″-O-, 4′,6′-O- and 4″,6″-O-Derivatives in the Kanamycin Series Indicate Differing Target Selectivity Patterns between the 4,5- and 4,6-Series of Disubstituted 2-Deoxystreptamine Aminoglycoside Antibiotics

4. Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design, Synthesis and Activity Evaluation Against Drug‐Resistant Bacteria of 6’‐Amidine Modified Aminoglycoside Derivatives;ChemistrySelect;2024-02-16

2. Effectiveness and safety of co-administration of moxifloxacin with netilmicin in drug-resistant tuberculosis patients, and its impact on inflammatory factors and immune function;Tropical Journal of Pharmaceutical Research;2022-01-28

3. Aminoglycosides with Anti-MRSA Activity: A Concise Review;Current Topics in Medicinal Chemistry;2021-12-08