Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens-Reference-Cited by-同舟云学术

Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens

Published:2019-02-22 Issue:12 Volume:141 Page:5051-5061
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Matsushita Takahiko¹,Sati Girish C.¹,Kondasinghe Nuwan¹,Pirrone Michael G.¹,Kato Takayuki¹,Waduge Prabuddha¹,Kumar Harshitha Santhosh²,Sanchon Adrian Cortes²,Dobosz-Bartoszek Malgorzata³,Shcherbakov Dimitri²,Juhas Mario²,Hobbie Sven N.²,Schrepfer Thomas⁴,Chow Christine S.¹,Polikanov Yury S.³⁵,Schacht Jochen⁴,Vasella Andrea⁶,Böttger Erik C.²,Crich David¹^ORCID

Affiliation:

1. Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, United States

2. Institut für Medizinische Mikrobiologie, Universität Zürich, 28 Gloriastrasse, 8006 Zürich, Switzerland

3. Department of Biological Sciences, University of Illinois at Chicago, 900 South Ashland Avenue, Chicago, Illinois 60607, United States

4. Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109, United States

5. Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 900 South Ashland Avenue, Chicago, Illinois 60607, United States

6. Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 1-5/10, 8093 Zürich, Switzerland

Funder

U.S. Department of Energy

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

National Institutes of Health

National Institute of General Medical Sciences

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.9b01693

Reference56 articles.

1. Armstrong, E. S.; Kostrub, C. F.; Cass, R. T.; Moser, H. E.; Serio, A. W.; Miller, G. H. In Antibiotic Discovery and Development; Dougherty, T. J., Pucci, M. J., Eds. Springer Science+Business Media: New York, 2012; pp 229–269.

2. Mechanisms of resistance to aminoglycoside antibiotics: overview and perspectives

3. Overcoming Aminoglycoside Enzymatic Resistance: Design of Novel Antibiotics and Inhibitors

4. Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

5. Aminoglycosides Modified by Resistance Enzymes Display Diminished Binding to the Bacterial Ribosomal Aminoacyl-tRNA Site

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