Syntheses and in vitro biological evaluation of S1PR1 ligands and PET studies of four F-18 labeled radiotracers in the brain of nonhuman primates-Reference-Cited by-同舟云学术

Syntheses and in vitro biological evaluation of S1PR1 ligands and PET studies of four F-18 labeled radiotracers in the brain of nonhuman primates

Published:2018 Issue:47 Volume:16 Page:9171-9184
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Luo Zonghua¹²³⁴^ORCID,Han Junbin¹²³⁴,Liu Hui¹²³⁴^ORCID,Rosenberg Adam J.¹²³⁴^ORCID,Chen Delphine L.¹²³⁴,Gropler Robert J.¹²³⁴,Perlmutter Joel S.¹²³⁴⁵^ORCID,Tu Zhude¹²³⁴^ORCID

Affiliation:

1. Department of Radiology

2. Washington University School of Medicine

3. St Louis

4. USA

5. Departments of Neurology

Abstract

Four potent and selective F-18 labeled S1PR1 radiotracers were radiosynthesized and three of them were able to cross blood–brain-barrier and enter into the brain of nonhuman primates.

Funder

National Institute of Neurological Disorders and Stroke

National Institute on Aging

National Institute of Biomedical Imaging and Bioengineering

U.S. Department of Energy

American Parkinson Disease Association

Foundation for Barnes-Jewish Hospital

National Institute of Mental Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry