Design, synthesis, and biological evaluation of multiple F-18 S1PR1 radiotracers in rodent and nonhuman primate-Reference-Cited by-同舟云学术

Design, synthesis, and biological evaluation of multiple F-18 S1PR1 radiotracers in rodent and nonhuman primate

Published:2024 Issue:26 Volume:22 Page:5428-5453
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Qiu Lin¹^ORCID,Jiang Hao¹^ORCID,Zhou Charles¹,Tangadanchu Vijai Kumar Reddy¹^ORCID,Wang Jinzhi¹,Huang Tianyu¹^ORCID,Gropler Robert J.¹^ORCID,Perlmutter Joel S.¹²^ORCID,Benzinger Tammie L. S.¹^ORCID,Tu Zhude¹^ORCID

Affiliation:

1. Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA

2. Department of Neurology, Neuroscience, Physical Therapy and Occupational Therapy, Washington University School of Medicine, Saint Louis, Missouri, 63110, USA

Abstract

We synthesized and screened 28 new fluorine-containing S1PR1 compounds; 9 potent and selective compounds were F-18 radiolabeled with good radiochemical yields. In vivo PET imaging evaluation was performed for these radiotracers as CNS imaging agents.

Funder

National Institutes of Health

National Institute of Biomedical Imaging and Bioengineering

American Parkinson Disease Association

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00712C

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