Assembly of fluorinated benzodiazepines via Rh(<scp>iii</scp>)-catalysed [5+2] annulation of N-benzo[d]imidazole indolines with 2,2-difluorovinyl tosylate-Reference-Cited by-同舟云学术

Assembly of fluorinated benzodiazepines via Rh(iii)-catalysed [5+2] annulation of N-benzo[d]imidazole indolines with 2,2-difluorovinyl tosylate

Published:2023 Issue:27 Volume:47 Page:12589-12594
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Liu Fu-Xiaomin¹²,Chen Weijie²,Ma Lei²,Cheng Kui¹^ORCID,Zhou Zhi²^ORCID,Yi Wei²^ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of New Drug Screening and Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, P. R. China

2. Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 511436, P. R. China

Abstract

Solvent-tunable Rh(iii)-catalysed C–H activation/[5+2] annulation of N-benzo[d]imidazole indolines with 2,2-difluorovinyl tosylate was realized for building monofluorinated and gem-difluorinated benzodiazepines.

Funder

National Natural Science Foundation of China

Guangzhou Municipal Science and Technology Project

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D3NJ01544K

Reference47 articles.

1. Structure–Affinity and Structure–Kinetic Relationship Studies of Benzodiazepine Derivatives for the Development of Efficacious Vasopressin V₂ Receptor Antagonists

2. A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling

3. Assessment of elementary derivatives of 1,5-benzodiazepine as anticancer agents with synergy potential

4. Identification of 2-Anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as Dual PLK1/VEGF-R2 Kinase Inhibitor Chemotypes by Structure-Based Lead Generation

5. Palladium-Catalyzed C-N Coupling in the Synthesis of 1,4-Benzodiazepines Fused with 5-Membered Carbo- and Heterocycles

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