Palladium-Catalyzed C-N Coupling in the Synthesis of 1,4-Benzodiazepines Fused with 5-Membered Carbo- and Heterocycles-Reference-Cited by-同舟云学术

Palladium-Catalyzed C-N Coupling in the Synthesis of 1,4-Benzodiazepines Fused with 5-Membered Carbo- and Heterocycles

Published:2022-10 Issue:20 Volume:26 Page:1827-1847
ISSN:1385-2728
Container-title:Current Organic Chemistry
language:en
Short-container-title:COC

Author:

Kaur Navjeet¹²^ORCID,Bhardwaj Pranshu¹

Affiliation:

1. Department of Chemistry, Banasthali Vidyapith, Banasthali, 304022 Rajasthan, India

2. Department of Chemistry & Division of Research and Development, Lovely Professional University, Phagwara, 144411 Punjab, India

Abstract

Abstract: In this review, we have focused our attention on Pd-catalyzed amination and arylation reactions for the construction of various benzodiazepine scaffolds. It includes numerous types of synthetic strategies like C-H arylation, Pd-catalyzed carbonylation, and Buchwald Hartwig coupling. To synthesize different functionalized benzodiazepines, the domino processes as intra- or intermolecular reactions are developed as an eco-friendly and effective tool. Benzodiazepines exhibit several biological activities and play a valuable role in medicinal and pharmaceutical chemistry. This review article mainly focuses on synthesizing a 1,4- benzodiazepine nucleus fused with 5-membered carbo- and heterocycles in the presence of palladium catalysts.

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

Reference258 articles.

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2. Kaur N.; Metal catalysts: applications in higher-membered N-heterocycles synthesis. J Indian Chem Soc 2015,12(1),9-45

3. Kaur N.; Palladium-catalyzed approach to the synthesis of S-heterocycles. Catal Rev, Sci Eng 2015,57(4),478-564

4. Kaur N.; Copper catalysts in the synthesis of five-membered N-polyheterocycles. Curr Org Synth 2018,15(7),940-971

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