Identification of 2-Anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as Dual PLK1/VEGF-R2 Kinase Inhibitor Chemotypes by Structure-Based Lead Generation-Reference-Cited by-同舟云学术

Identification of 2-Anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as Dual PLK1/VEGF-R2 Kinase Inhibitor Chemotypes by Structure-Based Lead Generation

Published:2010-02-19 Issue:6 Volume:53 Page:2433-2442
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Egert-Schmidt Anne-Marie¹,Dreher Jan¹,Dunkel Ute¹,Kohfeld Simone¹,Preu Lutz¹,Weber Holger²,Ehlert Jan E.²,Mutschler Bettina²,Totzke Frank²,Schächtele Christoph²,Kubbutat Michael H. G.²,Baumann Knut¹,Kunick Conrad¹

Affiliation:

1. Technische Universität Braunschweig, Institut für Pharmazeutische Chemie, Beethovenstrasse 55, 38106 Braunschweig, Germany

2. ProQinase GmbH, Breisacher Strasse 117, 79106 Freiburg, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901388c

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2. Die kurze Geschichte der Proteinkinase-Inhibitoren. Jung, kompetitiv, erfolgreich