Kinetics analysis and automated online screening of aminocarbonylation of aryl halides in flow-Reference-Cited by-同舟云学术

Kinetics analysis and automated online screening of aminocarbonylation of aryl halides in flow

Published:2016 Issue:3 Volume:1 Page:272-279
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Moore Jason S.¹²³⁴⁵,Smith Christopher D.¹²³⁴⁶,Jensen Klavs F.¹²³⁴

Affiliation:

1. Department of Chemical Engineering

2. Massachusetts Institute of Technology

3. Cambridge

4. USA

5. The Dow Chemical Company

6. Department of Chemistry

Abstract

The Pd-catalyzed aminocarbonylation of aromatic bromides was investigated in both a silicon microreactor and a packed-bed tubular reactor. An automated transient temperature ramp method with in-line IR analysis led to significantly more rapid determination of reaction kinetics than traditional steady-state screening for offline GC analysis.

Funder

Novartis

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RE/C6RE00007J

Reference36 articles.

1. Metal-catalysed approaches to amide bond formation

2. Palladium-Catalyzed Carbonylation Reactions of Aryl Halides and Related Compounds

3. Palladium-Catalyzed Carbonylation—A Reaction Come of Age