Simultaneous reaction- and analytical model building using dynamic flow experiments to accelerate process development-Reference-Cited by-同舟云学术

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Simultaneous reaction- and analytical model building using dynamic flow experiments to accelerate process development

Published:2024 Issue:31 Volume:15 Page:12523-12533
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Sagmeister Peter¹²^ORCID,Melnizky Lukas¹²,Williams Jason D.¹²^ORCID,Kappe C. Oliver¹²^ORCID

Affiliation:

1. Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010 Graz, Austria

2. Center for Continuous Flow Synthesis and Processing (CC FLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria

Abstract

By making use of a flow standard addition approach and dynamic flow experiments, we present an automated workflow for the fitting of analytical and reaction models, followed by in silico optimization, within one working day.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC01703J

Reference69 articles.

1. Organic Synthesis: March of the Machines

2. Development of the Commercial Manufacturing Process for Nirmatrelvir in 17 Months

3. A lightspeed approach to pandemic drug development

4. How to Scale Up a Lifesaving Molecule in a Matter of Months

5. The Path to Paxlovid

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