Catalytic mechanism of phenylacetone monooxygenases for non-native linear substrates
Author:
Affiliation:
1. School of Chemistry and Chemical Engineering
2. Queen's University
3. Belfast BT9 5AG
4. UK
5. Almac Sciences
6. Department of Biocatalysis and Isotope Chemistry
7. Craigavon BT63 5QD
8. School of Biological Sciences
Abstract
In this work, we provide, for the first time, the catalytic mechanism of PAMO for the native substrate phenylacetone as well as for a linear non-native substrate 2-octanone.
Publisher
Royal Society of Chemistry (RSC)
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://pubs.rsc.org/en/content/articlepdf/2017/CP/C7CP03640J
Reference56 articles.
1. Engineering the third wave of biocatalysis
2. Mutagenic PCR.
3. Rapid evolution of a protein in vitro by DNA shuffling
4. A General Method for Saturation Mutagenesis of Cloned DNA Fragments
5. DNA shuffling of a family of genes from diverse species accelerates directed evolution
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