Biocatalytic Baeyer–Villiger Reactions: Uncovering the Source of Regioselectivity at Each Evolutionary Stage of a Mutant with Scrutiny of Fleeting Chiral Intermediates

Author:

Dong Yijie12,Li Tang3ORCID,Zhang Shiqing45,Sanchis Joaquin6,Yin Heng3ORCID,Ren Jie1,Sheng Xiang45ORCID,Li Guangyue1ORCID,Reetz Manfred T.47ORCID

Affiliation:

1. State Key Laboratory for Biology of Plant Diseases and Insect Pests/Key Laboratory of Control of Biological Hazard Factors (Plant Origin) for Agri-product Quality and Safety, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China

2. Key Laboratory of Agricultural Microbiomics and Precision Application − Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Guangdong Microbial Culture Collection Center (GDMCC), Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, PR China

3. Liaoning Provincial Key Laboratory of Carbohydrates, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116023, PR China

4. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China

5. National Center of Technology Innovation for Synthetic Biology, Tianjin 300308, P.R. China

6. Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia

7. Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, Mülheim 45470, Germany

Funder

Chinese Academy of Agricultural Sciences

Max-Planck-Gesellschaft

National Natural Science Foundation of China

Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project

Agricultural Science and Technology Innovation Program of CAAS

Publisher

American Chemical Society (ACS)

Subject

Catalysis,General Chemistry

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