Thebaine is Selectively Demethylated by Thebaine 6-O-Demethylase and Codeine-3-O-demethylase at Distinct Binding Sites: A Computational Study-Reference-Cited by-同舟云学术

Thebaine is Selectively Demethylated by Thebaine 6-O-Demethylase and Codeine-3-O-demethylase at Distinct Binding Sites: A Computational Study

Published:2021-07-02 Issue:14 Volume:60 Page:10199-10214
ISSN:0020-1669
Container-title:Inorganic Chemistry
language:en
Short-container-title:Inorg. Chem.

Author:

Singh Warispreet¹,Hui Chenggong¹,Li Chun²,Huang Meilan¹^ORCID

Affiliation:

1. Department of Chemistry & Chemical Engineering, Queen’s University, Belfast BT9 5AG, United Kingdom

2. Key Lab of Industrial Biocatalysis Ministry of Education, Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, P. R. China

Funder

UK Research and Innovation

Invest Northern Ireland

European Regional Development Fund

Publisher

American Chemical Society (ACS)

Subject

Inorganic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.inorgchem.1c00468

Reference66 articles.

1. Complete biosynthesis of opioids in yeast

2. Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli

3. Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy

4. Biocatalysts from alkaloid producing plants

5. Dioxygenases Catalyze O-Demethylation and O,O-Demethylenation with Widespread Roles in Benzylisoquinoline Alkaloid Metabolism in Opium Poppy

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