Complete biosynthesis of opioids in yeast-Reference-Cited by-同舟云学术

Complete biosynthesis of opioids in yeast

Published:2015-09-04 Issue:6252 Volume:349 Page:1095-1100
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Galanie Stephanie¹,Thodey Kate²,Trenchard Isis J.²,Filsinger Interrante Maria²,Smolke Christina D.²

Affiliation:

1. Department of Chemistry, Stanford University, Stanford, CA 94305, USA.

2. Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.

Abstract

Toward opioids without poppy fields Producing opioids without having to depend on field-grown poppies would be of great benefit. Synthetic production could potentially produce more-effective drugs with fewer side effects. Now, Galanie et al. have engineered yeast to produce the opioid compounds thebaine and hydrocodone, starting from sugar (see the Perspective by Nielsen). The amounts produced so far are tiny compared with what would be needed commercially. Future optimization and scaleup are the next challenge. Science , this issue p. 1095 ; see also p. 1050

Funder

NSF

NIH

Stanford University

ARCS Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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5. The Quest for a Practical Synthesis of Morphine Alkaloids and Their Derivatives by Chemoenzymatic Methods

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