Application of rational enzyme engineering in a new route to etonogestrel and levonorgestrel: carbonyl reductase bioreduction of ethyl secodione-Reference-Cited by-同舟云学术

Application of rational enzyme engineering in a new route to etonogestrel and levonorgestrel: carbonyl reductase bioreduction of ethyl secodione

Published:2024 Issue: Volume:252 Page:450-467
ISSN:1359-6640
Container-title:Faraday Discussions
language:en
Short-container-title:Faraday Discuss.

Author:

Dourado Daniel F. A. R.¹^ORCID,Rowan Andrew S.¹^ORCID,Maciuk Sergej¹^ORCID,Brown Gareth¹^ORCID,Gray Darren¹^ORCID,Spratt Jenny¹^ORCID,Carvalho Alexandra T. P.¹^ORCID,Pavlović Dražen¹^ORCID,Tur Fernando¹^ORCID,Caswell Jill¹^ORCID,Quinn Derek J.¹^ORCID,Moody Thomas S.¹^ORCID,Mix Stefan¹^ORCID

Affiliation:

1. Almac Sciences, Department of Biocatalysis and Isotope Chemistry, UK

Abstract

We combine the selection and engineering of a carbonyl reductase enzyme with process development, to enable efficient and economically viable bioreduction of ethyl secodione to (13R,17S)-secol, the key chirality introducing intermediate en route to contraceptives etonogestrel and levonorgestrel.

Funder

Bill and Melinda Gates Foundation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FD/D4FD00011K

Reference63 articles.

1. H. N.Carcio and M. C.Secor , Advanced Health Assessment of Women: Clinical Skills and Procedures , Springer Publishing Company, LLC , New York , 3rd edn, 2015

2. E. J.Mayeaux , The Essential Guide to Primary Care Procedures , LWW , 1st edn, 2012

3. Analogue-based Drug Discovery , ed. J. Fischer and C. R. Ganellin , Wiley , 1st edn, 2006

4. K.Roth , Chemische Leckerbissen , Wiley-VCH Verlag GmbH & Co. KGaA , Weinheim , 2016 , vol. 2

5. An Improved Synthesis of optically Active Steroids