Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors M1and M2-Reference-Cited by-同舟云学术

Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors M1and M2

Published:2017 Issue:6 Volume:8 Page:1346-1359
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Messerer Regina¹²³⁴⁵,Dallanoce Clelia⁶⁷⁸⁹¹⁰,Matera Carlo⁶⁷⁸⁹¹⁰,Wehle Sarah¹²³⁴⁵,Flammini Lisa¹¹¹²¹³¹⁰,Chirinda Brian¹⁴¹⁵¹⁶¹⁷⁵,Bock Andreas¹⁸³¹⁹⁵,Irmen Matthias¹⁴¹⁵¹⁶¹⁷⁵,Tränkle Christian¹⁴¹⁵¹⁶¹⁷⁵,Barocelli Elisabetta¹¹¹²¹³¹⁰,Decker Michael¹²³⁴⁵,Sotriffer Christoph¹²³⁴⁵,De Amici Marco⁶⁷⁸⁹¹⁰,Holzgrabe Ulrike¹²³⁴⁵^ORCID

Affiliation:

1. Pharmaceutical and Medicinal Chemistry

2. Institute of Pharmacy and Food Chemistry

3. University of Würzburg

4. 97074 Würzburg

5. Germany

6. Dipartimento di Scienze Farmaceutiche

7. Sezione di Chimica Farmaceutica “Pietro Pratesi”

8. Università degli Studi di Milano

9. 20133 Milano

10. Italy

11. Dipartimento di Farmacia

12. Università degli Studi di Parma

13. 43124 Parma

14. Pharmacology and Toxicology

15. Institute of Pharmacy

16. University of Bonn

17. 53121 Bonn

18. Institute of Pharmacology and Toxicology

19. 97078 Würzburg

Abstract

Hybrids of allosteric modulators of the muscarinic receptor and the AChE inhibitor tacrine and the orthosteric muscarinic agonists iperoxo and isox were synthesized.

Funder

Studienstiftung des Deutschen Volkes

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00149E

Reference59 articles.

1. Deutsche Alzheimer Gesellschaft , Factsheet “Das Wichtigste 1 – Die Häufigkeit von Demenzerkrankungen”, 2014

2. Alzheimer's disease

3. Acetylcholinesterase — new roles for an old actor

4. Cholinesterase inhibitors: new roles and therapeutic alternatives

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