Discovery of AZD8165 – a clinical candidate from a novel series of neutral thrombin inhibitors-Reference-Cited by-同舟云学术

Discovery of AZD8165 – a clinical candidate from a novel series of neutral thrombin inhibitors

Published:2016 Issue:2 Volume:7 Page:272-281
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Abrahamsson K.¹²³⁴,Andersson P.⁵²³⁴,Bergman J.¹²³⁴,Bredberg U.¹²³⁴,Brånalt J.¹²³⁴,Egnell A.-C.¹²³⁴,Eriksson U.¹²³⁴,Gustafsson D.¹²³⁴,Hoffman K.-J.¹²³⁴,Nielsen S.¹²³⁴,Nilsson I.¹²³⁴,Pehrsson S.¹²³⁴,Polla M. O.¹²³⁴,Skjaeret T.¹²³⁴,Strimfors M.¹²³⁴,Wern C.¹²³⁴,Ölwegård-Halvarsson M.¹²³⁴,Örtengren Y.¹²³⁴

Affiliation:

1. Cardiovascular and Metabolic Disorders iMed

2. AstraZeneca R&D Mölndal

3. SE-431 83 Mölndal

4. Sweden

5. Drug Safety and Metabolism

Abstract

A novel series of neutral thrombin inhibitors has been developed using a selection process based on docking experiments and property calculations and predictions.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C5MD00479A

Reference27 articles.

1. Oral, Direct Thrombin and Factor Xa Inhibitors: The Replacement for Warfarin, Leeches, and Pig Intestines?

2. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials

3. Absorption, Distribution, Metabolism, and Excretion of Ximelagatran, an Oral Direct Thrombin Inhibitor, in Rats, Dogs, and Humans

4. Discovery and Clinical Evaluation of 1-{N-[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor with an Oxyguanidine P1 Motif

5. Fluorobenzamidrazone thrombin inhibitors: Influence of fluorine on enhancing oral absorption

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