Absorption, Distribution, Metabolism, and Excretion of Ximelagatran, an Oral Direct Thrombin Inhibitor, in Rats, Dogs, and Humans

Author:

Eriksson Ulf G.,Bredberg Ulf,Hoffmann Kurt-Jürgen,Thuresson Anneli,Gabrielsson Margareth,Ericsson Hans,Ahnoff Martin,Gislén Kristina,Fager Gunnar,Gustafsson David

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference25 articles.

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2. Antonsson T Bylund R Gustafsson D Nilsson I (1994) inventors, Trypsin-like protease-inhibiting peptide derivatives, their synthesis and therapeutic use. PTC patent application WO 94/29336.

3. Antonsson T Gustafsson D Hoffmann K-J Nyström J-E Sörensen H Sellén M (1997) inventors, Preparation of peptide derivatives as prodrug of thrombin inhibitors. PTC patent application WO 97/23499.

4. Evaluation of using dog as an animal model to study the fraction of oral dose absorbed of 43 drugs in humans.;Chiou;Pharm Res (NY),2000

5. Clement B (1998) inventor, Pharmaceutical preparation. Patent application US 5,786,383.

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