Discovery and Clinical Evaluation of 1-{N-[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor with an Oxyguanidine P1 Motif-Reference-Cited by-同舟云学术

Discovery and Clinical Evaluation of 1-{N-[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor with an Oxyguanidine P1 Motif

Published:2010-01-26 Issue:4 Volume:53 Page:1843-1856
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lu Tianbao¹,Markotan Thomas¹,Ballentine Shelley K.¹,Giardino Edward C.¹,Spurlino John¹,Brown Kathryn¹,Maryanoff Bruce E.¹,Tomczuk Bruce E.¹,Damiano Bruce P.¹,Shukla Umesh¹,End David¹,Andrade-Gordon Patricia¹,Bone Roger F.¹,Player Mark R.¹

Affiliation:

1. Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901802n

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