Ring expansion and ring opening of 3-halooxindoles with N-alkoxycarbonyl-O-tosylhydroxylamines for divergent access to 4-aminoquinolin-2-ones and N-Cbz-N’-arylureas
Author:
Affiliation:
1. Institute for Advanced Study
2. Chengdu University
3. Chengdu 610106
4. China
5. National Engineering Research Center of Chiral Drugs
6. Chengdu Institute of Organic Chemistry
7. Chinese Academy of Sciences
8. Chengdu
Abstract
The reaction of N-alkoxycarbonyl-O-tosylhydroxylamines with indol-2-ones in situ generated from 3-halooxindoles has been developed for divergently accessing 4-aminoquinolin-2-ones and N-Cbz-N’-arylureas in good to excellent yields.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Ministry of Public Security of the People's Republic of China
Chengdu University
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/QO/D0QO01335H
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