Discovery of Inducible Nitric Oxide Synthase (iNOS) Inhibitor Development Candidate KD7332, Part 1: Identification of a Novel, Potent, and Selective Series of Quinolinone iNOS Dimerization Inhibitors that are Orally Active in Rodent Pain Models
Author:
Affiliation:
1. Department of Chemistry, Department of Biology, Department of Pharmacology, Department of Drug Metabolism and Pharmacokinetics, Department of Analytical Chemistry, Kalypsys Inc., 10420 Wateridge Circle, San Diego, CA 92121
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm900173b
Reference36 articles.
1. Blocking NO synthesis: how, where and why?
2. Nitric oxide synthases: structure, function and inhibition
3. NO Pain: Potential Roles of Nitric Oxide in Neuropathic Pain
4. Pharmacologic Manipulation of Nitric Oxide Signaling: Targeting NOS Dimerization and Protein-Protein Interactions
5. GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthasein vitroandin vivo
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