Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies

Author:

Taghour Mohammed S.1,Elkady Hazem1,Eldehna Wagdy M.23,El-Deeb Nehal M.4,Kenawy Ahmed M.5,Elkaeed Eslam B.6,Alsfouk Aisha A.7ORCID,Alesawy Mohamed S.1,Metwaly Ahmed M.48,Eissa Ibrahim. H.1ORCID

Affiliation:

1. Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt

3. School of Biotechnology, Badr University in Cairo, Badr City, Cairo, Egypt

4. Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, Egypt

5. Nucleic Acids Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, Egypt

6. Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia

7. Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

8. Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

Funder

Princess Nourah bint Abdulrahman University Researchers

Princess Nourah bint Abdulrahman University

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

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