Flexibility is important for inhibition of the MDM2/p53 protein–protein interaction by cyclic β-hairpins-Reference-Cited by-同舟云学术

Flexibility is important for inhibition of the MDM2/p53 protein–protein interaction by cyclic β-hairpins

Published:2016 Issue:44 Volume:14 Page:10386-10393
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Danelius Emma¹²³⁴,Pettersson Mariell¹²³⁴,Bred Matilda¹²³⁴,Min Jaeki⁵⁶⁷⁸,Waddell M. Brett⁹⁶⁷⁸,Guy R. Kiplin⁵⁶⁷⁸,Grøtli Morten¹²³⁴,Erdelyi Mate¹²³⁴¹⁰^ORCID

Affiliation:

1. Department of Chemistry and Molecular Biology

2. University of Gothenburg

3. SE-41296 Gothenburg

4. Sweden

5. Department of Chemical Biology and Therapeutics

6. St. Jude Children's Research Hospital

7. Memphis

8. USA

9. Molecular Interaction Analysis Shared Resource

10. Swedish NMR Centre

Abstract

Overrigidification should be avoided in the design of β-hairpin based inhibitors of MDM2.

Funder

Vetenskapsrådet

European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01510G

Reference69 articles.

1. Protein−Protein Interactions: Interface Structure, Binding Thermodynamics, and Mutational Analysis

2. Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

3. Small-Molecule Inhibitors of the MDM2–p53 Protein–Protein Interaction (MDM2 Inhibitors) in Clinical Trials for Cancer Treatment

4. Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

5. Oncogenic protein interfaces: small molecules, big challenges

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