A concise route to MK-4482 (EIDD-2801) from cytidine-Reference-Cited by-同舟云学术

A concise route to MK-4482 (EIDD-2801) from cytidine

Published:2020 Issue:87 Volume:56 Page:13363-13364
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Vasudevan N.¹²³,Ahlqvist Grace P.⁴⁵⁶³^ORCID,McGeough Catherine P.⁴⁵⁶³,Paymode Dinesh J.¹²³,Cardoso Flavio S. P.¹²³^ORCID,Lucas Tobias⁴⁷⁸⁹,Dietz Jule-Phillip⁴⁷⁸⁹,Opatz Till⁴⁷⁸⁹^ORCID,Jamison Timothy F.⁴⁵⁶³^ORCID,Gupton Frank B.¹²³,Snead David R.¹²³^ORCID

Affiliation:

1. Medicines for All Institute

2. Richmond

3. USA

4. Department of Chemistry

5. Massachusetts Institute of Technology

6. Cambridge

7. Johannes Gutenberg University

8. Mainz 55128

9. Germany

Abstract

A two-step route to MK-4482 (EIDD-2801, 1) was developed consisting of an esterification and hydroxamination of cytidine.

Funder

Bill and Melinda Gates Foundation

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC05944G

Reference16 articles.

1. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

2. Quest for a COVID-19 Cure by Repurposing Small-Molecule Drugs: Mechanism of Action, Clinical Development, Synthesis at Scale, and Outlook for Supply

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