A path from synthesis to emergency use authorization of molnupiravir as a COVID-19 therapy

Author:

Sakander Norein,Ahmed Ajaz,Bhardwaj Mahir,Kumari Diksha,Nandi Utpal,Mukherjee Debaraj

Funder

Council of Scientific and Industrial Research, India

University Grants Commission

Publisher

Elsevier BV

Reference123 articles.

1. (a). “Summary of Product Characteristics for Lagevrio”.Medicines and Healthcare products Regulatory Agency(MHRA). 4 November 2021.Archivedfrom the original on 4 November 2021. Retrieved4 November2021; (b). Focosi, D. Molnupiravir: From Hope to Epic Fail?Viruses2022,14, 2560; (c). Pagliano P, Sellitto C, Ascione T, Scarpati G, Folliero V, Piazza O, Franci G, Filippelli A, Conti V. The preclinical discovery and development of molnupiravir for the treatment of SARS-CoV-2 (COVID-19). Expert Opin Drug Discov.2022 Dec;17(12):1299-1311; (d). Yip AJW, Low ZY, Chow VTK, Lal SK. Repurposing Molnupiravir for COVID-19: The Mechanisms of Antiviral Activity. Viruses. 2022 Jun 20;14(6):1345.

2. Toots, M.; Yoon, J.J.; Cox, R. M.; Hart, M.; Sticher, Z.M.; Makhsous, N. ;Plesker, R. ; Barrena, A.H.; Reddy, P.G.; Mitchell, D.G.; Shean, R.C.; Blueming, G.R.;. Kolykhalov, A.A.; Greninger, A.L.; Natchus, M.G.; Painter, G.R.; Plemper, R.K. Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci TranslMed2019, 11(515).

3. Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model;Toots;Translational Research,2020

4. Sheahan,T. P.; Sims, A.C.; Zhou, S.; Graham,R.L.; Pruijssers,A.J.; Agostini, M.L.;Leist,S. R.; Schäfer,A.; Dinnon, K.H.; Stevens, L.J.; Chappell, J.D.; Lu,X.; Hughes, T.M.; George, A.S.; Hill, C.S.; Montgomery,S.A.; Brown,A.J.; Bluemling,G.R.; Natchus, M.G.;Saindane, M.; Kolykhalov, A.A.;Painter,J,; G.;Harcourt,Tamin,A.;Thornburg,N.J.;Swanstrom, R.; . Denison, M.R.; Baric, R.S.; An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med2020, 12(541).

5. Beta-D-N(4)-hydroxycytidine is a potent anti-alphavirus compound that induces high level of mutations in viral genome;Urakova;Journal of Virology,2018

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