Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia-Reference-Cited by-同舟云学术

Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia

Published:2019-10-23 Issue:515 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Toots Mart¹^ORCID,Yoon Jeong-Joong¹^ORCID,Cox Robert M.¹,Hart Michael¹^ORCID,Sticher Zachary M.²^ORCID,Makhsous Negar³,Plesker Roland⁴^ORCID,Barrena Alec H.¹^ORCID,Reddy Prabhakar G.²,Mitchell Deborah G.²,Shean Ryan C.³^ORCID,Bluemling Gregory R.²^ORCID,Kolykhalov Alexander A.²,Greninger Alexander L.³^ORCID,Natchus Michael G.²,Painter George R.²⁵,Plemper Richard K.¹^ORCID

Affiliation:

1. Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.

2. Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.

3. Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.

4. Veterinary Medicine Division, Paul-Ehrlich-Institute, Federal Institute for Vaccines and Biomedicines, 63225 Langen, Germany.

5. Department of Pharmacology, Emory University, Atlanta, GA 30322, USA.

Abstract

A next-generation, broad-spectrum, orally efficacious influenza A and B virus inhibitor is associated with a high genetic resistance barrier.

Funder

National Institute of Allergy and Infectious Diseases

National Institute of Child Health and Human Development

Defense Threat Reduction Agency

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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