Development of a Large-Scale Cyanation Process Using Continuous Flow Chemistry En Route to the Synthesis of Remdesivir
Author:
Affiliation:
1. Gilead Alberta ULC, 1021 Hayter Road, Edmonton, Alberta T6S 1A1, Canada
2. Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00172
Reference17 articles.
1. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
2. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
3. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
4. First Case of 2019 Novel Coronavirus in the United States
5. Compassionate Use of Remdesivir for Patients with Severe Covid-19
Cited by 60 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Enabling technologies applied to glycosylation;Carbohydrate Chemistry;2024-07-03
2. Electrocatalytic Hydrogen Evolution Reaction Enabling Cyanation of Electron‐poor Carbons with Acetone Cyanohydrin;European Journal of Organic Chemistry;2024-05-17
3. Pilot-Scale Operation and Characterization of an Organolithium-Mediated Coupling Reaction in Flow to Form a Ketone Intermediate on the Route to Nemtabrutinib;Organic Process Research & Development;2024-05-09
4. Flow Synthesis of Capsaicin and Capsaicinoid Analogues;ACS Sustainable Chemistry & Engineering;2024-05-09
5. A cyanide-free synthesis of nitriles exploiting flow chemistry;Reaction Chemistry & Engineering;2024
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3