Development of Scalable Processes for the Preparation of 4-(chloromethyl)-1-cyclohexyl-2-(trifluoromethyl)benzene: A Key Intermediate for Siponimod-Reference-Cited by-同舟云学术

Development of Scalable Processes for the Preparation of 4-(chloromethyl)-1-cyclohexyl-2-(trifluoromethyl)benzene: A Key Intermediate for Siponimod

Published:2023-07-21 Issue:8 Volume:27 Page:1474-1484
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Lin Biyue¹²³,Wu Shuming²³,Xiao Qingbo²,Kou Jingping²,Hu Ji’an²,Zhu Zhu²,Zhou Xinglin²,Weng Jiang¹^ORCID,Wang Zhongqing²³⁴^ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China

2. HEC Research and Development Center, HEC Pharm Group, Dongguan 523871, P. R. China

3. Anti-infection Innovation Department, New Drug Research Institute, HEC Pharm Group, Dongguan 523871, P. R. China

4. School of Pharmacy, Xiangnan University, Chenzhou 423000, Hunan, China

Funder

Guangdong Science and Technology Department

State Key Laboratory of Anti-Infective Drug Development

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.3c00170

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