Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses-Reference-Cited by-同舟云学术

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Published:2017-06-28 Issue:396 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Sheahan Timothy P.¹^ORCID,Sims Amy C.¹^ORCID,Graham Rachel L.¹^ORCID,Menachery Vineet D.¹,Gralinski Lisa E.¹^ORCID,Case James B.²,Leist Sarah R.¹,Pyrc Krzysztof³^ORCID,Feng Joy Y.⁴^ORCID,Trantcheva Iva⁴,Bannister Roy⁴^ORCID,Park Yeojin⁴,Babusis Darius⁴^ORCID,Clarke Michael O.⁴^ORCID,Mackman Richard L.⁴^ORCID,Spahn Jamie E.⁴^ORCID,Palmiotti Christopher A.⁴^ORCID,Siegel Dustin⁴,Ray Adrian S.⁴^ORCID,Cihlar Tomas⁴,Jordan Robert⁴,Denison Mark R.⁵,Baric Ralph S.¹^ORCID

Affiliation:

1. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

2. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

3. Department of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.

4. Gilead Sciences Inc., Foster City, CA 94404, USA.

5. Division of Infectious Diseases, Department of Pediatrics and Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Abstract

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses in vitro and in vivo.

Funder

National Heart, Lung, and Blood Institute

National Institute of Allergy and Infectious Diseases

Cystic Fibrosis Foundation

Gilead Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference34 articles.