Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses-Reference-Cited by-同舟云学术

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

Published:2017-01-26 Issue:5 Volume:60 Page:1648-1661
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Siegel Dustin¹,Hui Hon C.¹,Doerffler Edward¹,Clarke Michael O.¹,Chun Kwon¹,Zhang Lijun¹,Neville Sean¹,Carra Ernest¹,Lew Willard¹,Ross Bruce¹,Wang Queenie¹,Wolfe Lydia¹,Jordan Robert¹,Soloveva Veronica²,Knox John¹,Perry Jason¹,Perron Michel¹,Stray Kirsten M.¹,Barauskas Ona¹,Feng Joy Y.¹,Xu Yili¹,Lee Gary¹,Rheingold Arnold L.³,Ray Adrian S.¹,Bannister Roy¹,Strickley Robert¹,Swaminathan Swami¹,Lee William A.¹,Bavari Sina²,Cihlar Tomas¹,Lo Michael K.⁴,Warren Travis K.²,Mackman Richard L.¹^ORCID

Affiliation:

1. Gilead Sciences, Inc., Foster City, California 94404, United States

2. United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, Maryland 21702, United States

3. University of California—San Diego, San Diego, California 92093, United States

4. Centers for Disease Control and Prevention, Atlanta, Georgia 30333, United States

Funder

Centers for Disease Control and Prevention

Defense Threat Reduction Agency

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01594

Reference46 articles.

1. World Health Organization. Ebola Situation Report—10 June 2016. http://apps.who.int/iris/bitstream/10665/208883/1/ebolasitrep_10Jun2016_eng.pdf?ua=1 (accessed Jul. 22, 2016).

2. World Health Organization. Ebola Data and Statistics—11 May 2016. http://apps.who.int/gho/data/view.ebola-sitrep.ebola-summary-20160511?lang=en (accessed Jul. 22, 2016).

3. Ebola Virus Shedding and Transmission: Review of Current Evidence

4. Molecular Evidence of Sexual Transmission of Ebola Virus

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