Flow technology enabled preparation of C3-heterosubstituted 1-azabicyclo[1.1.0]butanes and azetidines: accessing unexplored chemical space in strained heterocyclic chemistry-Reference-Cited by-同舟云学术

Flow technology enabled preparation of C3-heterosubstituted 1-azabicyclo[1.1.0]butanes and azetidines: accessing unexplored chemical space in strained heterocyclic chemistry

Published:2022 Issue:43 Volume:58 Page:6356-6359
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Musci Pantaleo¹,Colella Marco¹^ORCID,Andresini Michael¹^ORCID,Aramini Andrea²,Degennaro Leonardo¹^ORCID,Luisi Renzo¹^ORCID

Affiliation:

1. FLAME-Lab, Flow Chemistry and Microreactor Technology Laboratory, Department of Pharmacy – Drug Sciences, University of Bari “A. Moro” Via E. Orabona 4, 70125, Bari, Italy

2. Department of Discovery, Dompé Farmaceutici S.p.A., Via Campo di Pile, L’Aquila, 67100, Italy

Abstract

The use of flow technology as an enabling tool for accessing 1-azabicyclo[1.1.0]butanes bearing strained 3-, 4-, and 5-membered O-heterocycles with C3(N-het)–C2(O-het) connectivity is reported.

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC01641A

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