Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules-Reference-Cited by-同舟云学术

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Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

Published:2010-09-21 Issue:1 Volume:1 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Galloway Warren R.J.D.,Isidro-Llobet Albert,Spring David R.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms1081.pdf

Reference86 articles.

1. Burke, M. D. & Schreiber, S. L. A planning strategy for diversity-oriented synthesis. Angew. Chem., Int. Ed. 43, 46–58 (2004). A seminal introduction to diversity-oriented synthesis (DOS) and a discussion of various planning strategies in DOS.

2. Schreiber, S. L. The small-molecule approach to biology. Chem. Eng. News. 81, 51–61 (2003).

3. Galloway, W. R. J. D., Bender, A., Welch, M. & Spring, D. R. The discovery of antibacterial agents using diversity-oriented synthesis. Chem. Commun. 2446–2462 (2009).

4. Kaiser, M., Wetzel, S., Kumar, K. & Waldmann, H. Biology-inspired synthesis of compound libraries. Cell. Mol. Life. Sci. 65, 1186–1201 (2008).

5. Spring, D. R. Chemical genetics to chemical genomics: small molecules offer big insights. Chem. Soc. Rev. 34, 472–482 (2005).

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