Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
Author:
Affiliation:
1. 200 Cambridgepark Drive, Cambridge, Massachusetts 02140
2. 401 North Middletown Road, Pearl River, New York 10965
3. 865 Ridge Road, Monmouth Junction, New Jersey 08543
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm901241e
Reference40 articles.
1. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
2. Molecular Properties That Influence the Oral Bioavailability of Drug Candidates
3. Generation of a Set of Simple, Interpretable ADMET Rules of Thumb
4. A Bioavailability Score
5. Medicinal chemical properties of successful central nervous system drugs
Cited by 3082 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Visible light–driven organic synthesis under other miscellaneous photocatalysis;Visible Light-Driven Organic Synthesis;2025
2. 3,4-difluoro-2-(((4-phenoxyphenyl)imino)methyl)phenol with in silico predictions: Synthesis, spectral analyses, ADME studies, targets and biological activity, toxicity and adverse effects, site of metabolism, taste activity;Journal of Molecular Structure;2024-12
3. In silico ADMET and DFT analysis of methoxy substituted curcumin derivatives;Inorganic Chemistry Communications;2024-10
4. A novel 7-phenoxy-benzimidazole derivative as a potent and orally available BRD4 inhibitor for the treatment of melanoma;Bioorganic & Medicinal Chemistry;2024-10
5. Exploring monocyclic core: Discovery of pyrrol-2-one derivatives as a new series of potent MCHR1 antagonists with in vivo efficacy;European Journal of Medicinal Chemistry;2024-10
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3